Treatment of Kala-Azar with Pentamidine Isothionate. A Study of 55 Cases

Trial of Pentamidine Isothionate in Kala-Azar Cases in the Patna Medical College Hospital (Preliminary Report)

The Treatment of Kala-Azar with Sodium Antimony-V-Gluconate: Preliminary Observations *The work reported in this paper was undertaken under the Endowment Fund of the Calcutta School of Tropical Medicine, aided by a grant from the Indian Research Fund Association.

A pentavalent antimony compound (Sdt. 561, solustibosan, antimony-v-hexonate, containing 20 mg. of antimony per c.cm. of solution) , that made a stable solution and could be given intramuscularly, was first introduced b) Prof. H. Schmidt, the pioneer worker on pent*1' valent antimony compounds. Kikuth and Schmidt (1938) found that this compound possessed a marked curative action in the le*,' ma...

Hydroxy Stilbamidine in the Treatment of Kala-Azar

hvdroxy stilbenc di-isothionate, is one of the aromatic diamidine compounds synthesized by Dr. A. J. Ewins, f.b.s. During the last four months, I have treated six cases of kala-azar with this drug at the School of Tropical Medicine. Calcutta. All the patients were admitted into the hospital of the School and the diagnosis was confirmed by finding the parasite, in spleen, sternum or tibia punctu...

Drug unresponsiveness & combination therapy for kala-azar.

Pentavalent antimonials (SbV) have been successfully used for treatment of kala-azar since last six decades. Since 1970s its conventional dosages have failed to achieve with 60 per cent unresponsiveness reported with WHO regimen in Bihar (India). Pentamidine initially used as a second line of drug, acquired resistance (25%) even with prolonged dosage. Newer oral drug miltefosine is a potent ant...

بیماریابی کالا آزار با استفاده از روش آگلوتیناسیون مستقیم

Visceral leishmaniasis (VL) has been found as an endemic disease in some areas in northwest and south parts of Iran during recent two decades. The species of the Leishmania has been characterized as L.infantum and the main sources of human infection in the endemic areas is dog. The majority of kala-azar cases are found among children in the age group of 1-4 years. As the delay in diagnosis and ...